- #Clobetasol propionate ointment skin
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Some corticosteroids have been shown to be teratogenic after dermal application to laboratory animals.Ĭlobetasol propionate has not been tested for teratogenicity when applied topically however, it is absorbed percutaneously, and when administered subcutaneously it was a significant teratogen in both the rabbit and mouse. Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. Teratogenic Effects: Pregnancy Category C If a favorable response does not occur promptly, use of Clobetasol Propionate Ointment USP should be discontinued until the infection has been adequately controlled.
#Clobetasol propionate ointment skin
If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used.
#Clobetasol propionate ointment Patch
Such an observation should be corroborated with appropriate diagnostic patch testing. Allergic contact dermatitis with corticosteroids is usually diagnosed by observing aįailure to heal rather than noting a clinical exacerbation as with most topical products not containing corticosteroids.
If irritation develops, Clobetasol Propionate Ointment USP should be discontinued and appropriate therapy instituted. Pediatric patients may be more susceptible to systemic toxicity from equivalent doses due to their larger skin surface to body mass ratios (see For information on systemic supplementation, see prescribing information for those products. Infrequently, signs and symptoms of glucocorticosteroid insufficiency may occur requiring supplemental systemic corticosteroids. Recovery of HPA axis function is generally prompt upon discontinuation of topical corticosteroids.
If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid. Patients receiving super-potent corticosteroids should not be treated for more than 2 weeks at a time and only small areas should be treated at any one time due to the increased risk of HPA suppression.Ĭlobetasol Propionate Ointment USP produced HPA axis suppression when used at doses as low as 2 g/day for 1 week in patients with eczema.
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plasma cortisol, and urinary free cortisol tests. This may be done by using the ACTH stimulation, A.M. Patients applying a topical steroid to a large surface area or to areas under occlusion should be evaluated periodically for evidence of HPA axis suppression.
Manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on therapy. Systemic absorption of topical corticosteroids can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal from treatment. Using these medicines together may cause serious unwanted effects.ĭo not use cosmetics or other skin care products on the treated areas.Clobetasol Propionate Ointment USP should not be used in the treatment of rosacea or perioral dermatitis, and should not be used on the face, groin, or axillae. You may need to stop using this medicine several days before having surgery.ĭo not use clobetasol together with other topical corticosteroid-containing medicines, such as betamethasone, hydrocortisone, triamcinolone, Cortaid®, or Lotrisone®. Make sure your doctor knows that you are using clobetasol cream, gel, or spray. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).Ĭheck with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin. Talk to your doctor right away if you or your child have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness.Ĭheck with your doctor right away if blurred vision, difficulty with reading, or any other change in vision occurs during or after treatment. The risk is greater for children and patients who use large amounts for a long time. Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.
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